Time: Wed 12.2. at 15-16
Topic: Cancer, VUS and molecular modelling in personal medicine
Speaker: Prof. Antti Poso, School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland (Kuopio).
Get to know the speaker: Antti Poso – UEFConnect
This time the webinar is organised by FICAN East. The seminar will be held online (Microsoft Teams) and is open to everyone interested in cancer research.
Link: Join the meeting (Teams)
Abstract:
The range of cancer drugs is extensive, and gene sequencing offers opportunities for personalized treatment selection. Designing personalized treatment requires multidisciplinary collaboration, and often, computer models of drug targets can assist in selecting cancer medications. Sequencing identifies mutations present in cancer, and models can be used to study how these mutations affect the efficacy of cancer drugs. For instance, a mutation may prevent a cancer drug from binding to its target protein, rendering the medication ineffective for the patient. While the use of computer models to aid in cancer drug selection has been employed to some extent globally, it remains rare in Finland. By leveraging information on mutation-induced changes in protein structures, the most effective cancer drug can be chosen. Creating and studying computer models is rapid, providing information on drug suitability in hours or, at most, a few days. Additionally, I will present several case examples from Germany to illustrate this approach in practice.
Relevat references for this talk:
- Kuittinen, Poso, Bartos: Lääkkeen vaikutuskohteen tietokonemalleista apua yksilöidyn syöpälääkkeen valintaan. Duodecim, 2024, 140, 1703-1709
- S. Spahn, F. Kleinhenz, E. Shevchenko, A. Stahl, Y. Rasen, C. Geisler, et al., Nat. Commun. 2024, 15, 1287.
